Journal: Cutis
Article Title: BRAF V600E Expression in Primary Melanoma and Its Association With Death: A Population-Based, Retrospective, Cross-Sectional Study
doi: 10.12788/cutis.0515
Figure Lengend Snippet: Examples of staining of melanocytes in melanomas for BRAF V600E. A, Negative cytoplasmic staining of melanoma melanocytes. Positive and negative controls that were run simultaneously with each specimen showed appropriate reactivity. All examples had immunohistochemical staining (anti-BRAF V600E, clone VEI; original magnification ×10). B, Focal or partial positive (<50% of tumor cells) cytoplasmic staining of melanoma melanocytes. C, Diffuse positive (>50% of tumor cells) cytoplasmic staining of melanoma melanocytes.
Article Snippet: The available tissue blocks were retrieved, sectioned, confirmed as melanoma, and stained with a mouse antihuman BRAF V600E monoclonal antibody (clone VE1; Spring Bioscience) to determine the presence of a BRAF V600E mutation.
Techniques: Staining, Immunohistochemical staining